Plenary 1: Medical Imaging/Clinical Applications

Sunday, April 5, 17:30 - 18:30

Anant Madabhushi, Case Western Reserve University

Artificial Intelligence and Computational Pathology: Implications for Precision Medicine

Abstract: With the advent of digital pathology, there is an opportunity to develop computerized image analysis methods to not just detect and diagnose disease from histopathology tissue sections, but to also attempt to predict risk of recurrence, predict disease aggressiveness and long term survival. At the Center for Computational Imaging and Personalized Diagnostics, our team has been developing a suite of image processing and computer vision tools, specifically designed to predict disease progression and response to therapy via the extraction and analysis of image-based “histological biomarkers” derived from digitized tissue biopsy specimens. These tools would serve as an attractive alternative to molecular based assays, which attempt to perform the same predictions. The fundamental hypotheses underlying our work are that: 1) the genomic expressions detected by molecular assays manifest as unique phenotypic alterations (i.e. histological biomarkers) visible in the tissue; 2) these histological biomarkers contain information necessary to predict disease progression and response to therapy; and 3) sophisticated computer vision algorithms are integral to the successful identification and extraction of these biomarkers. We have developed and applied these prognostic tools in the context of several different disease domains including ER+ breast cancer, prostate cancer, Her2+ breast cancer, ovarian cancer, and more recently medulloblastomas. For the purposes of this talk I will focus on our work in breast, prostate, rectal, oropharyngeal, and lung cancer.

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Madabhushi

 

Michael D. Feldman, University of Pennsylvania

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Feldman

 

Plenary 2: Pushing limits: Microscopy, Computational Image Reconstruction, Bioimaging

Monday, April 6, 17:30 - 18:30

Rebecca Willett, University of Chicago

Learning to Solve Inverse Problems in Imaging

Abstract: Many challenging image processing tasks can be described by an ill-posed linear inverse problem: deblurring, deconvolution, tomographic reconstruction, MRI reconstruction, inpainting, compressed sensing, and superresolution all lie in this framework. Traditional inverse problem solvers minimize a cost function consisting of a data-fit term, which measures how well an image matches the observations, and a regularizer, which reflects prior knowledge and promotes images with desirable properties like smoothness. Recent advances in machine learning and image processing have illustrated that it is often possible to learn a regularizer from training data that can outperform more traditional regularizers. Recent advances in machine learning have illustrated that it is often possible to learn a regularizer from training data that can outperform more traditional regularizers. In this talk, I will describe various classes of approaches to learned regularization, ranging from generative models to unrolled optimization perspectives, and explore their relative merits and sample complexities. We will also explore the difficulty of the underlying optimization task and how learned regularizers relate to oracle estimators.

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Willett

 

Willy Supatto, Ecole Polytechnique

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Supatto